Gene description for ITGA2B
Gene name	integrin subunit alpha 2b
Gene symbol	ITGA2B
Other names/aliases	BDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GT1 GTA HPA3 PPP1R93
Species	Homo sapiens
Experiment description of studies that identified ITGA2B in Platelets
1 Experiment ID 152 Identified molecule protein Extracellular vesicle type Microvesicles MISEV EVs Identification method FACS PubMed ID 22064971    Organism Homo sapiens Experiment description Oxidized low-density lipoprotein-dependent platelet-derived microvesicles trigger procoagulant effects and amplify oxidative stress Authors Wang H, Wang ZH, Kong J, Yang MY, Jiang GH, Wang XP, Zhong M, Zhang Y, Deng JT, Zhang W Journal name Mol Med Publication year 2011 Sample Platelets Sample name Platelets Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study FACS ELISA EV-TRACK -
2 Experiment ID 294 Identified molecule protein Extracellular vesicle type Microvesicles MISEV EVs Identification method Western blotting PubMed ID 2071604    Organism Homo sapiens Experiment description Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets Authors Fox JE, Austin CD, Reynolds CC, Steffen PK Journal name J Biol Chem Publication year 1991 Sample Platelets Sample name Platelets Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
3 Experiment ID 369 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 16212402    Organism Homo sapiens Experiment description The platelet microparticle proteome. Authors Garcia BA, Smalley DM, Cho H, Shabanowitz J, Ley K, Hunt DF. Journal name J Proteome Res Publication year 2005 Sample Platelets Sample name Normal donors-Platelets Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
4 Experiment ID 406 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 19806257    Organism Homo sapiens Experiment description Proteomic and functional characterisation of platelet microparticle size classes. Authors Dean WL, Lee MJ, Cummins TD, Schultz DJ, Powell DW. Journal name Thromb Haemost Publication year 2009 Sample Platelets Sample name Normal donors-Platelets Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
5 Experiment ID 520 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 23601281    Organism Homo sapiens Experiment description Proteomic characterization of human platelet-derived microparticles. Authors Capriotti AL, Caruso G, Cavaliere C, Piovesana S, Samperi R, Laganà A. Journal name Anal Chim Acta Publication year 2013 Sample Platelets Sample name Platelets purifird from blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
6 Experiment ID 2529 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Western blotting Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (thrombin-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Lipid Methods used in the study Western blotting Immuno-EM Flow cytometry EV-TRACK -
7 Experiment ID 3504 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Western blotting PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
8 Experiment ID 3505 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Western blotting PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
9 Experiment ID 3495 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry Western blotting PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Flow cytometry EV-TRACK -
10 Experiment ID 3498 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry Western blotting PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Flow cytometry EV-TRACK -
11 Experiment ID 1344 Identified molecule protein Extracellular vesicle type Platelet-derived microparticles MISEV EV-like nanoparticles Identification method Flow cytometry PubMed ID 33009394    Organism Homo sapiens Experiment description Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p Authors Qu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X. Journal name Nat Commun Publication year 2020 Sample Platelets Sample name Platelets derived from umbilical cord blood Isolation/purification methods Ficoll-Hypaque density gradient centrifugation Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein miRNA Methods used in the study Flow cytometry Western blotting qPCR EV-TRACK -
12 Experiment ID 2530 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (thrombin-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
13 Experiment ID 2531 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (thrombin-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
14 Experiment ID 2532 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (thrombin-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
15 Experiment ID 2533 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (thrombin-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
16 Experiment ID 2534 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (thrombin-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
17 Experiment ID 2535 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (ADP-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
18 Experiment ID 2536 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (CRP-XL-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
19 Experiment ID 2537 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Large EVs Identification method Flow cytometry PubMed ID 34293122    Organism Homo sapiens Experiment description Platelet EVs contain an active proteasome involved in protein processing for antigen presentation via MHC-I molecules Authors Marcoux G, Laroche A, Hasse S, Bellio M, Mbarik M, Tamagne M, Allaeys I, Zufferey A, Lévesque T, Rebetz J, Karakeussian-Rimbaud A, Turgeon J, Bourgoin SG, Hamzeh-Cognasse H, Cognasse F, Kapur R, Semple JW, Hébert MJ, Pirenne F, Overkleeft HS, Florea BI, Dieude M, Vingert B, Boilard E. Journal name Blood Publication year 2021 Sample Platelets Sample name Platelets (HA-IgG-activated) - healthy volunteers Isolation/purification methods Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
20 Experiment ID 3496 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
21 Experiment ID 3497 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
22 Experiment ID 3499 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
23 Experiment ID 3500 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
24 Experiment ID 3501 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
25 Experiment ID 3502 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -
26 Experiment ID 3503 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Flow cytometry PubMed ID 31160588    Organism Homo sapiens Experiment description Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2 Authors Sung PS, Huang TF, Hsieh SL. Journal name Nat Commun Publication year 2019 Sample Platelets Sample name Peripheral blood of healthy donors Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Flow cytometry EV-TRACK -