Gene description for HEG1
Gene name heart development protein with EGF like domains 1
Gene symbol HEG1
Other names/aliases HEG
MST112
MSTP112
Species Homo sapiens
 Experiment description of studies that identified HEG1 in Plasma

1
Experiment ID2329
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 32487994   
OrganismHomo sapiens
Experiment descriptionPlasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
AuthorsToda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA.
Journal name Nat Commun
Publication year2020
SamplePlasma
Sample nameHealthy donors
Isolation/purification methodsCentrifugation
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
Mass spectrometry
Flow cytometry
EV-TRACK -

2
Experiment ID2330
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 32487994   
OrganismHomo sapiens
Experiment descriptionPlasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence
AuthorsToda H, Diaz-Varela M, Segui-Barber J, Roobsoong W, Baro B, Garcia-Silva S, Galiano A, Gualdrón-López M, Almeida ACG, Brito MAM, de Melo GC, Aparici-Herraiz I, Castro-Cavadía C, Monteiro WM, Borràs E, Sabidó E, Almeida IC, Chojnacki J, Martinez-Picado J, Calvo M, Armengol P, Carmona-Fonseca J, Yasnot MF, Lauzurica R, Marcilla A, Peinado H, Galinski MR, Lacerda MVG, Sattabongkot J, Fernandez-Becerra C, Del Portillo HA.
Journal name Nat Commun
Publication year2020
SamplePlasma
Sample namePlasmodium vivax (Malaria) patients
Isolation/purification methodsCentrifugation
Size exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyWestern blotting
Mass spectrometry
Flow cytometry
EV-TRACK -

3
Experiment ID2378
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 14
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

4
Experiment ID2379
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 15
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

5
Experiment ID2380
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 16
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

6
Experiment ID2381
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 17
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

7
Experiment ID2382
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 18
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

8
Experiment ID2383
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 19
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

9
Experiment ID2384
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 20
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

10
Experiment ID2385
Identified moleculeProtein
Extracellular vesicle typeExtracellular vesicles
MISEVSmall EVs
Identification method Mass spectrometry
PubMed ID 34355211   
OrganismHomo sapiens
Experiment descriptionA size-exclusion-based approach for purifying extracellular vesicles from human plasma
AuthorsVanderboom PM, Dasari S, Ruegsegger GN, Pataky MW, Lucien F, Heppelmann CJ, Lanza IR, Nair KS.
Journal name Cell Rep Methods
Publication year2021
SamplePlasma
Sample nameSEC Fraction 21
Isolation/purification methodsSize exclusion chromatography
Flotation density-
Molecules identified in the studyProtein
Methods used in the studyMass spectrometry
EV-TRACK -

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