Gene description for APOA1
Gene name	apolipoprotein A1
Gene symbol	APOA1
Other names/aliases	HPALP2 apo(a)
Species	Homo sapiens
Experiment description of studies that identified APOA1 in Plasma
1 Experiment ID 353 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [Orbitrap Velos] PubMed ID 24115447    Organism Homo sapiens Experiment description Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma Authors Mathivanan,S. Journal name Proteomics Publication year 2013 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [Orbitrap Velos] Western blotting EV-TRACK EV130073: EV-METRIC:0%, 11%, 33%, 33%, 56%
2 Experiment ID 354 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry [Orbitrap Velos] PubMed ID 24115447    Organism Homo sapiens Experiment description Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma Authors Mathivanan,S. Journal name Proteomics Publication year 2013 Sample Plasma Sample name Plasma - Normal Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Density gradient centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [Orbitrap Velos] Western blotting EV-TRACK EV130073: EV-METRIC:0%, 11%, 33%, 33%, 56%
3 Experiment ID 454 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 22669077    Organism Homo sapiens Experiment description The proteome of erythrocyte-derived microparticles from plasma: new clues for erythrocyte aging and vesiculation. Authors Bosman GJ, Lasonder E, Groenen-Döpp YA, Willekens FL, Werre JM. Journal name J Proteomics Publication year 2012 Sample Plasma Sample name Normal-Blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
4 Experiment ID 473 Identified molecule protein Extracellular vesicle type Microparticles MISEV EVs Identification method Mass spectrometry PubMed ID 23056467    Organism Homo sapiens Experiment description Cause or Effect of Arteriogenesis: Compositional Alterations of Microparticles from CAD Patients Undergoing External Counterpulsation Therapy. Authors Al Kaabi A, Traupe T, Stutz M, Buchs N, Heller M. Journal name PLoS One Publication year 2012 Sample Plasma Sample name Patients of external counterpulsation therapy-Blood Isolation/purification methods - Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
5 Experiment ID 863 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 22046311    Organism Mus musculus Experiment description Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections Authors Martin-Jaular L, Nakayasu ES, Ferrer M, Almeida IC, Del Portillo HA. Journal name PLoS One Publication year 2011 Sample Plasma Sample name Peripheral blood plasma - P. yoelii 17X infected Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study FACS Mass spectrometry EV-TRACK EV110102: EV-METRIC:25%, 25%
6 Experiment ID 1075 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25104112    Organism Homo sapiens Experiment description Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. Authors Sarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C. Journal name J Transl Med Publication year 2014 Sample Plasma Sample name Fresh plasma- healthy women Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation Flotation density 1.12-1.19 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140094: EV-METRIC:56%
7 Experiment ID 1076 Identified molecule protein Extracellular vesicle type Exosomes MISEV EVs Identification method Mass spectrometry PubMed ID 25104112    Organism Homo sapiens Experiment description Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy. Authors Sarker S, Scholz-Romero K, Perez A, Illanes SE, Mitchell MD, Rice GE, Salomon C. Journal name J Transl Med Publication year 2014 Sample Plasma Sample name Stored plamsa(freeze/thaw) plasma- healthy women Isolation/purification methods Differential centrifugation Ultracentrifugation Filtration Density gradient centrifugation Flotation density 1.12-1.19 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV140094: EV-METRIC:56%
8 Experiment ID 1223 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 1 Isolation/purification methods Exo-spin Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
9 Experiment ID 1224 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 2 Isolation/purification methods Exo-spin Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
10 Experiment ID 1225 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 3 Isolation/purification methods Exo-spin Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
11 Experiment ID 1226 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar 1 fr7+8 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
12 Experiment ID 1228 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV EVs Identification method Mass spectrometry PubMed ID 26154623    Organism Homo sapiens Experiment description Size-exclusion chromatography as a stand-alone methodology identifies novel markers in mass spectrometry analyses of plasma-derived vesicles from healthy individuals Authors de Menezes-Neto A, Sá MJ, Lozano-Ramos I, Segui-Barber J, Martin-Jaular L, Ullate JM, Fernandez-Becerra C, BorráFE, Del Portillo HA. Journal name J Extracell Vesicles. Publication year 2015 Sample Plasma Sample name Donar fr11 Isolation/purification methods Size exclusion chromatography Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK EV150034: EV-METRIC:17%, 57%
13 Experiment ID 2128 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 36515353    Organism Homo sapiens Experiment description Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin Authors Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, Kapogiannis D, Martens CR. Journal name Aging Cell Publication year 2023 Sample Plasma Sample name Patient-derived neuronal origin EVs (enriched) Isolation/purification methods ExoQuick Kit Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
14 Experiment ID 2129 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 36515353    Organism Homo sapiens Experiment description Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin Authors Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, Kapogiannis D, Martens CR. Journal name Aging Cell Publication year 2023 Sample Plasma Sample name Patient-derived neuronal origin EVs (total) Isolation/purification methods ExoQuick Kit Centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting EV-TRACK -
15 Experiment ID 2267 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 36624553    Organism Homo sapiens Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles Authors Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. Journal name Proteomics Publication year 2023 Sample Plasma Sample name Plasma Isolation/purification methods Filtration Size exclusion chromatography Centrifugal ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
16 Experiment ID 2268 Identified molecule Protein Extracellular vesicle type Small extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 36624553    Organism Homo sapiens Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles Authors Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. Journal name Proteomics Publication year 2023 Sample Plasma Sample name Plasma - Ion exchange adsorption 12.5 mg Isolation/purification methods Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
17 Experiment ID 2269 Identified molecule Protein Extracellular vesicle type Small extracellular vesicles MISEV Small EVs Identification method Western blotting PubMed ID 36624553    Organism Homo sapiens Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles Authors Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. Journal name Proteomics Publication year 2023 Sample Plasma Sample name Plasma - Ion exchange adsorption 25 mg Isolation/purification methods Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
18 Experiment ID 2267 Identified molecule Protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 36624553    Organism Homo sapiens Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles Authors Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. Journal name Proteomics Publication year 2023 Sample Plasma Sample name Plasma Isolation/purification methods Filtration Size exclusion chromatography Centrifugal ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
19 Experiment ID 2268 Identified molecule Protein Extracellular vesicle type Small extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 36624553    Organism Homo sapiens Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles Authors Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. Journal name Proteomics Publication year 2023 Sample Plasma Sample name Plasma - Ion exchange adsorption 12.5 mg Isolation/purification methods Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
20 Experiment ID 2269 Identified molecule Protein Extracellular vesicle type Small extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 36624553    Organism Homo sapiens Experiment description Combination of size-exclusion chromatography and ion exchange adsorption for improving the proteomic analysis of plasma-derived extracellular vesicles Authors Wang Y, Zhang Y, Li Z, Wei S, Chi X, Yan X, Lv H, Zhao L, Zhao L. Journal name Proteomics Publication year 2023 Sample Plasma Sample name Plasma - Ion exchange adsorption 25 mg Isolation/purification methods Filtration Size exclusion chromatography Ion exchange adsorption Centrifugation Centrifugal ultrafiltration Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
21 Experiment ID 2848 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-001 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
22 Experiment ID 2849 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name NWL-004 - Lung cancer patient Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -
23 Experiment ID 2850 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name CSB-012 - COVID-19 patient - convalescent phase Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry EV-TRACK -
24 Experiment ID 2851 Identified molecule protein Extracellular vesicle type Extracellular vesicles MISEV Small EVs Identification method Mass spectrometry PubMed ID 35058437    Organism Homo sapiens Experiment description Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 Authors El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, Mao C, Felicelli CJ, Tsai CF, Ostiguin C, Jia Y, Li L, Furlong K, Wysocki J, Luo X, Ruivo CF, Batlle D, Hope TJ, Shen Y, Chae YK, Zhang H, LeBleu VS, Shi T, Swaminathan S, Luo Y, Missiakas D, Randall GC, Demonbreun AR, Ison MG, Kalluri R, Fang D, Liu H. Journal name Nat Commun Publication year 2022 Sample Plasma Sample name CSB-024 - COVID-19 patient - convalescent phase Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry EV-TRACK -