latest news

01/09/2013 - Vesiclepedia Version 2.1 released!!

01/09/2013 - Addition of new datasets to Vesiclepedia.

01/04/2013 - Vesiclepedia highlighted in Nature Methods

01/04/2013 - Manuscript describing Vesiclepedia was highlighted in the tool section of Nature Methods.

19/12/2012 - Vesiclepedia published in PLOS Biology

19/12/2012 - Manuscript describing Vesiclepedia published in PLOS Biology.

29/08/2012 - 50 laboratories from 19 countries in Vesiclepedia community annotation

29/08/2012 - An enthusiastic participation from the extracellular vesicle researchers!!!!

19/04/2012 - Vesiclepedia oral presentation in ISEV conference in Gothenberg

19/04/2012 - An oral presentation on Vesiclepedia and the community annotation was presented in the ISEV conference that has expert researchers in extracellular vesicles. Researchers were supportive and enthusiastic about Vesiclepedia.

03/02/2012 - Vesiclepedia Manual Curation Stage 1 Completed!!!!

03/02/2012 - Statistics tab will give information on the curated data.

15/01/2012 - Vesiclepedia Data Capture Initiative

15/01/2012 - Researchers with longstanding reputation in extracellular vesicles form the Vesiclepedia Data Capture Initiative

05/07/2011 - Vesiclepedia Data Annotation Launched!!!!

05/07/2011 - Manual curation of the scientific literature to encompass molecular components (proteins, lipids, DNA and RNA) identified in extracellular vesicles is initiated. Additionally, the compendium has information on post-translational modification on proteins identified in extracellular vesicles.

 A community compendium for extracellular vesicles
 


Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into the extracellular microenvironment. Based on the mode of biogenesis, EVs can be classified into three broad classes (i), ectosomes or shedding microvesicles (ii), exosomes and (iii), apoptotic bodies. Recent studies have ignited significant interest on EVs by elucidating their role in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery and as possible reservoirs of biomarkers. With such immense interest, the amount of data generated has increased exponentially. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA and protein) identified in different classes of EVs. Currently, Vesiclepedia comprises 35,264 protein, 18,718 mRNA, 1,772 miRNA and 342 lipid entries encompassed from 341 independent studies that were published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not updated for a long time. In addition, more than 20% of the database links are not active after its initial publication. To prevent such database decay and keep them updated, for the first time, we have initiated a ‘continuous community annotation project with the active involvement of the EV researchers’ with long standing (> 10 years) and newly found reputation in the field. The principal investigators working on EVs have vowed to contribute data generated by their group in a regular and continuous fashion making this effort significantly unique. By undertaking such initiatives, we foresee the EV research community as trendsetters in data sharing. We expect, Vesiclepedia to evolve as a primary resource for EV research.

 

   Signaling of extracellular vesicles (exosomes as example)

Extracellular vesicles captured in Vesiclepedia:

1, Apoptotic blebs
2, Exosomes
3, Microparticles
4, Microvesicles


External links of interest to the extracellular vesicle researchers
Journal of Extracellular Vesicles

International Society for Extracellular Vesicles
 

Want to contribute to Vesiclepedia?
  We will keep Vesiclepedia updated with new extracellular vesicle studies. We welcome researchers to join the Vesiclepedia community annotation project.

 Send unpublished extracellular vesicle proteome/RNA/lipid datasets (it can be made private until published)
 Point out an extracellular vesicle publication that we missed

Contact us either to upload your exosome data or point to us if we have not added any published exosome study.